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Total 30877 results found since Jan 2013.
Antineoplastic drugs inducing cardiac and vascular toxicity - An update
Vascul Pharmacol. 2023 Sep 5:107223. doi: 10.1016/j.vph.2023.107223. Online ahead of print.ABSTRACTWith the improvement in cancer prognosis due to advances in antitumor therapeutic protocols and new targeted and immunotherapies, we are witnessing a growing increase in survival, however, at the same timeincrease in morbidity among cancer survivors as a consequences of the increased cardiovascular adverse effects of antineoplastic drugs. Common cardiovascular complications of antineoplastic therapies may include cardiac complications such as arrhythmias, myocardial ischemia, left ventricular dysfunction culminating in heart ...
Source: Vascular Pharmacology - September 7, 2023 Category: Drugs & Pharmacology Authors: Serena Barachini Sandra Ghelardoni Zolt án V Varga Radwa A Mehanna Maria Magdalena Montt-Guevara P éter Ferdinandy Rosalinda Madonna Source Type: research
Outcomes and factors influencing prognosis in patients with vascular pythiosis
Vascular pythiosis, caused by Pythium insidiosum, is associated with a high mortality rate. We reviewed the outcomes and established the factors predicting prognosis of patients treated in our institution with surgery, antifungal therapy, or immunotherapy.
Source: Journal of Vascular Surgery - March 4, 2016 Category: Surgery Authors: Nuttawut Sermsathanasawadi, Banjerd Praditsuktavorn, Kiattisak Hongku, Chumpol Wongwanit, Khamin Chinsakchai, Chanean Ruangsetakit, Suteekhanit Hahtapornsawan, Pramook Mutirangura Source Type: research
Systematic review of case reports of Bacillus Calmette-Guerin (BCG) vascular infections
Bacillus Calmette-Guerin (BCG) is a live attenuated strain of Mycobacterium bovis that has been used as immunotherapy against several malignancies. In particular, intravesical instillation of BCG has become a well-accepted adjuvant treatment for bladder cancer. BCG vascular infections are a rare complication of BCG therapy. Many aspects of these infections, including the presentations, risk factors and treatment strategies are poorly understood. Through a systematic review of the existing literature, we aimed to identify potential associations between this condition and patient characteristics, presentations, its treatments and outcomes.
Source: Annals of Vascular Surgery - March 3, 2022 Category: Surgery Authors: Kelvin Kam Fai Ho, Vidushi Lal, Daniel Hagley, John Bingley Tags: General Review Source Type: research
Systematic Review of Case Reports of Bacillus Calmette-Guerin Vascular Infections
Bacillus Calmette-Guerin (BCG) is a live attenuated strain of Mycobacterium bovis that has been used as immunotherapy against several malignancies. In particular, intravesical instillation of BCG has become a well-accepted adjuvant treatment for bladder cancer. BCG vascular infections are a rare complication of BCG therapy. Many aspects of these infections, including the presentations, risk factors, and treatment strategies, are poorly understood. Through a systematic review of the existing literature, we aimed to identify potential associations between this condition and patient characteristics, presentations, its treatments, and outcomes.
Source: Annals of Vascular Surgery - March 3, 2022 Category: Surgery Authors: Kelvin Kam Fai Ho, Vidushi Lal, Daniel Hagley, John Bingley Tags: General Review Source Type: research
Abstract IA24: Tolerability and efficacy of antiangiogenic agents and novel combinations - In search of the optimal therapeutic windows
Antiangiogenic agents are associated with toxicities due to "on-target" effects on neoangiogenesis, vascular dynamics and tissue repair as well as "off-target" side effects in the case of small molecular inhibitors. Nevertheless, the therapeutic window has proven to be adequate for conferring important clinical benefits in a number of advanced tumors. As antiangiogenic therapies became widely used in patient care, progresses have been made in the efforts to identify risk factors of serious adverse reactions and establish guidelines for risk mitigation. Still, therapeutic outcomes with individual agents are limited by the c...
Source: Molecular Cancer Therapeutics - December 6, 2015 Category: Cancer & Oncology Authors: Chen, H. X. Tags: Antiangiogenesis: Safety Issues and Endothelial Metabolism: Oral Presentations - Invited Abstracts Source Type: research
In Search of Treatments for Alzheimer ' s Disease in the Lymphatic System of the Brain
That the brain has a lymphatic system that drains into the body is a comparatively recently discovery, a development of the last decade of research. It isn't the only way in which fluids drain from the brain - see, for example, the work on the cribriform plate path for drainage of cerebrospinal fluid - but there are a limited number of such pathways outside the vascular system. The vascular system itself is separated from the brain by the blood-brain barrier that surrounds every blood vessel that passes through the central nervous system. This barrier controls the entry and exit of molecules and cells, limiting the degree ...
Source: Fight Aging! - May 14, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Oropharyngeal colostrum immunotherapy and risk reduction of mortality in very low birth weight premature newborns: A clinical trial
CONCLUSION: The OCI proved to be a beneficial intervention, since it reduced the risk of mortality in PTNB with VLBW when compared to the control group.PMID:37690464 | DOI:10.1016/j.jped.2023.07.007
Source: Jornal de Pediatria - September 10, 2023 Category: Pediatrics Authors: Camilla da C Martins Michelle de S X Ramos Amanda O Lyrio Tatiana de O Vieira Simone S da Cruz Graciete O Vieira Source Type: research
Vascular normalization in immunotherapy: A promising mechanisms combined with radiotherapy
Biomed Pharmacother. 2021 May 6;139:111607. doi: 10.1016/j.biopha.2021.111607. Online ahead of print.ABSTRACTLeakage and compression of blood vessels may result in deprivation of blood flow to a large number of tumor tissues, which can lead to tumor hypoxia. Hypoxia induces an increase in the expression of hypoxia-inducible factor 1 in tumor cells, which induces angiogenesis in tumors through the high expression of vascular endothelial growth factor, thereby forming a positive feedback vicious circle. Improving hypoxia by normalizing blood vessels and improving radiosensitivity by immunotherapy has emerged as a new applica...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 9, 2021 Category: Drugs & Pharmacology Authors: Zijing Liu Qin Zhao Zhuangzhuang Zheng Shiyu Liu Lingbin Meng Lihua Dong Xin Jiang Source Type: research
